
Webinar Information
Webinar Series on Biomolecules - an Open Access Journal
Role of Nrf2 in Neurodegeneration: Novel Molecular Mechanisms and Therapeutic Approaches
Neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are characterized by the presence of three main hallmarks: oxidative stress, neuroinflammation, and alterations in cellular proteostasis. Ever since its discovery, the transcription factor Nrf2 (nuclear factor erythroid-derived 2-like 2) has been implicated in processes associated with redox balance, inflammation, and proteostasis, among other mechanisms, representing a pleiotropic transcription factor. The function of Nrf2 is altered in these neurodegenerative diseases, and pharmacological activation of Nrf2 alleviates those three main hallmarks involved in neurodegeneration through the upregulation of antioxidant defenses, inhibition of inflammation, and modulation of protein homeostasis.
This webinar on Nrf2 will emphasize the importance of this transcription factor in neurodegenerative diseases and also highlight existing pharmacological components that can modify the Nrf2 signaling pathway.
This Webinar relates to the Special Issue Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches.
Date & Time: 16 October 2020 03:00pm (CEST)
Chair: Prof. Dr. Isabel Lastres-Becker
Speakers: Prof. Dr. Bianca Marchetti, Prof. Dr. Manuela G. López, Dr. Fabio Di Domenico
Webinar ID: 863 2534 8347
Webinar Secretariat: [email protected]
This webinar will include the following experts:
Webinar Program
The webinar will start at 3:00 pm (CEST) 16 October 2020 and will last 2 hours.
Presentation |
Time |
Prof. Dr. Isabel Lastres-Becker Introduction |
03:00 pm (CEST) |
Prof. Dr. Bianca Marchetti "Resilience of Nrf2-ARE axis and Wnt/β-catenin intertwined signaling cascades to fight ageing and nigrostriatal degeneration in Parkinson’s disease" |
03:20 pm (CEST) |
Q&A |
03:40 pm (CEST) |
Prof. Dr. Manuela G. López "NRF2: a therapeutic target for Alzheimer's disease" |
03:50 pm (CEST) |
Q&A |
04:10 pm (CEST) |
Dr. Fabio Di Domenico "The aberrant crosstalk between PERK and Nrf2 in Down syndrome: A novel target for therapeutic intervention" |
04:20 pm (CEST) |
Q&A |
04:40 pm (CEST) |
Discussion and Concluding Remarks |
04:50 pm (CEST) |
Webinar Content
The third Biomolecules webinar, entitled “Role of Nrf2 in Neurodegeneration: Novel Molecular Mechanisms and Therapeutic Approaches", was held on Friday 16 October, 2020. It was chaired by Prof. Dr. Isabel Lastres-Becker.
This online seminar emphasized the importance of Nrf2 transcription factor in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, and highlighted existing pharmacological components targeting the Nrf2 signaling pathway.
After an introduction given by the chair, Prof. Dr. Manuela G. López presented her research on “NRF2: a therapeutic target for Alzheimer's disease”. Dr. Fabio Di Domenico followed with a presentation on “The aberrant crosstalk between PERK and Nrf2 in Down syndrome: A novel target for therapeutic intervention”. Prof. Dr. Bianca Marchetti was the final speaker and spoke about “Resilience of Nrf2-ARE axis and Wnt/β-catenin intertwined signaling cascades to fight ageing and nigrostriatal degeneration in Parkinson’s disease”. All presentations were followed by a Q&A session moderated by the chair and a final discussion and Q&A session was also conducted to answer any remaining questions.
The webinar was offered via Zoom, and registration was required for attendance. The full recording can be found below.
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Relevant Special Issues
Special Issues in Biomolecules
Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches
Guest Editor: Prof. Dr. Isabel Lastres-Becker
Deadline for manuscript submissions: closed (31 August 2020).